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LDH assay and microscopy observations showed dose-dependent and time-dependent effects of PQS on macrophage cytotoxicity, respectively (Fig

Although we did not identify specific cell populations in our bulk transcriptomic analysis, macrophage activation was predicted in the immunized flight mice when compared to their saline-treated counterparts (Fig

Another compound that was identified as potent BACH1-inhibitor was the phytocannabinoid cannabidiol (CBD), which induces nuclear export and degradation of the transcription factor ( In vitro models have confirmed CBDs antioxidant and anti-inflammatory properties, acting through HMOX-1 and inducing the downregulation of pro-inflammatory cytokines (Juknat et al., 2016