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[138] In 1968, Pauling published a brief paper in Science entitled "Orthomolecular psychiatry", [139] giving a name to the popular but controversial megavitamin therapy movement of the 1970s, and advocating that "orthomolecular therapy, the provision for the individual person of the optimum concentrations of important normal constituents of the brain, may be the preferred treatment for many mentally ill patients." Pauling coined the term "orthomolecular" to refer to the practice of varying the concentration of substances normally present in the body to prevent and treat disease

1c and Extended Data Fig

Mycoplasma contamination was not tested

Targeting autophagy to diminish the CSCs subpopulation might be a new direction to overcome platinum resistance