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This vasorelaxation is mediated through actions on purinergic receptors, specifically adenosine receptors ( + regulates the activity of NADPH oxidase, a significant ROS source in vascular cells, thereby playing a key role in the modulation of vascular tone (Reid et al., 2018)

Activation of beta-3 adrenergic receptors stimulates adenylyl cyclase, an enzyme that converts ATP to cyclic AMP (cAMP)