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12 , 13 Opposite effects are observed in dysbiosis conditions (eg, a low Bacteroidetes to Firmicutes ratio), where high levels of lipopolysaccharides and pro-inflammatory cytokines (eg, interleukin-1, interleukin-6, tumor necrosis factor ) are produced by gut bacteria (Figure 1)
This lowers your chances of developing sagging skin due to weight loss

For gastrointestinal applications, digestive comfort may improve within the first 1 to 2 weeks, progressing to sustained improvements in food tolerances by weeks 5 to 6

Hrelec M, et al
