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CTR1 could amplify copper uptake, inducing mitochondrial copper accumulation, dysfunction, and reactive oxygen species (ROS) production, ultimately leading to cell death (Wee et al., 2013
& Uceyler, N
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Most pathogenic bacteria contain MnSOD or FeSOD in their cytoplasm, while CuZnSOD has been found on the periplasm of pathogenic bacteria and played an essential role during phagocytosis [11, 23]