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With respect to physiology, phosphorylation and cytosolic localization of HNF4 are linked with liver decompensation and cirrhosis, however evidence is lacking on the effect of phosphorylated HNF4 66

Under the selective pressure of DAAs, previously dominant high-replicating wild-type strains are eradicated, while low-replicating mutant strains with RASs present at low levels before treatment continue to survive during treatment at lower replication levels

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