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That's not speculation

Huge copper-mining operations were located in Pima and Pinal counties
Overgrowth of bacteria: Some people develop vitamin B 12 deficiency as a result of conditions that slow the movement of food through the intestines (diabetes, scleroderma, strictures, diverticula), allowing intestinal bacteria to multiply and overgrow in the upper part of the small intestine

These can enter the system through drinking water, non-organic food, or even older paint