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Description
Sidrauski, C., Cox, J
E., Jin, O., Fujiwara, Y., Kuo, F
A polyubiquitin chain attached to lysine residue labels the proteins intended for ATP-dependent proteolysis in proteasomes and stimulates various downstream signals involved, such as apoptosis, cell cycle control, NF-B activation, and DNA repair [58]
Manipulation of intracellular GSH pools by supplementation with GSH precursors was found to block induction of JNK activity by methylating agents [26] Similarly p53 function has been reported to be redox sensitive, primarily through in vitro modification of its cysteine residues [27]
