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Univariate statistical testing using two-sample t-tests with confirmation by Wilcoxon rank-sum tests identified four metabolitescoumarin, L-leucine, L-octanoylcarnitine, and kaempferolthat differed significantly between ASD and control groups after FDR correction, with large effect sizes (Supplementary Table S2)

For instance, PKC deletion in the whole body of mice protects against diet-induced obesity