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Women often describe this as their period coming back, but in most cases, it is a treatment-related response rather than a return of normal ovulation

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doi: 10.1007/s11120-005-8425-1

Also amplification of the CCNE2 gene (encoding cyclin E2) was seen in a fraction of CDK4/6-inhibitor-resistant resistant HR+ mammary carcinomas (145, 162)