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Notably, 2HG is a well-documented oncometabolite that exists as two enantiomers ( D and L forms) and is widely reported in many cancers ( D -2HG

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People with low B12 may experience: Persistent fatigue or low energy Weakness Brain fog, concentration issues, or memory changes Low mood or irritability Pins and needles, numbness, or nerve-type sensations Mouth ulcers or a sore tongue Paleness or shortness of breath (if anaemia is present) Some symptoms can become more serious if deficiency is prolonged, particularly neurological symptoms

These results indicate that B12 deficiency affects the levels of the cytokines in AT and circulation, thus inducing pro-inflammatory factors which could contribute to adipose dysfunction