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Description
The nuance is that a large share of autistic patients also show undermethylation traits, where aggressive folate therapy can occasionally activate irritability, anxiety, or sleep disruption

Parkinsonism Relat Disord 45:16
The study was not powered to assess the risk of progressive multifocal leukoencephalopathy, and 21% of patients in the extended-interval dosing group and 19% of patients in the every-4-weeks group had JCV Abs in the serum (30)

