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Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signaling

VDAC ubiquitination orchestrated by a pathway involving the PTEN induced kinase 1 kinase and the parkin RBR E3 ubiquitin protein ligase (PARKIN) ubiquitin ligase eliminates damaged mitochondria by autophagy (80)

A statement of the reasons for not classifying or retaining the device in class III may be in the form of concurrence with the reasons for the recommendation of the classification panel, together with supporting documentation and data satisfying the requirements of 860.7 and an identification of the risks to health, if any, presented by the device

however, Asian-Indian and Filipino individuals have been found to have higher risks than other racial groups