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This indicates that glutathione depletion downregulates Th1 immunity through a perturbation of DCs maturation and IL-12 production ( Nutrient and metabolite alterations occur in the TME and affect tumor-immune interactions ( As mentioned earlier, Glutamate lies in the intersection of multiple metabolic pathways and participates in the amino acid metabolic cycle through transamination reactions (e.g., glutamine transaminase/glutamine transaminase, ALT/AST) to produce -ketoglutarate (a TCA cycle intermediate), which connects carbon and nitrogen metabolism

This resulted in an increased bioavailability in an animal model owing to the mucoadhesive ability of hyaluronic acid [165]

132 Wang, F