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Increasing hydration modestly accelerates GHK-Cu clearance by supporting higher glomerular filtration rates, but the effect is limited because peptide clearance is primarily enzyme-limited, not filtration-limited

Taking peptides on an empty stomach causes a faster rise in their concentration in the blood

They are generally well tolerated topically

The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default