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Description
Simultaneous measurement of antibodies to EpsteinBarr virus, human herpesvirus 6, herpes simplex virus types 1 and 2, and 14 enteroviruses in chronic fatigue syndrome: is there evidence of activation of a nonspecific polyclonal immune response

Changes to the 2 position group can affect nucleic acid stability and affinity, 227 with common modifications including 2-fluoro (2-F), 2-O-methoxyethyl (2-MOE), and 2-O-methyl (2-OMe)

Jiang Q, Qiu Y, Kurland IJ, Drlica K, Subbian S, Tyagi S, Shi L

Above 8 is usually a sign of acute infection and below 5 is a sign of immune suppression
