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This paradoxical vulnerability indicates that GSH-dependent redox homeostasis, while essential for normal cellular function, can become a critical liability in cancer cells with dysregulated GSH metabolism

Glutathione, an endogenous antioxidant The GST enzymes conjugate (bind) an antioxidant called glutathione to the substance for elimination

doi: 10.5761/atcs.oa.21-00132 [DOI] [PMC free article] [PubMed] [Google Scholar] 38.Naughton F, Wijeysundera D, Karkouti K, et al

2024;3:e70000
