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Conversely, the overexpression of Erv1 led to a higher OxD at steady state in the IMS (Supplementary Figure S8)
In contrast, if metabolically competent human HepaRG cells [142] or primary human hepatocytes [46] were treated with 20 mM APAP for 24 h, there was 8090% GSH depletion, a ten-fold higher protein adducts formation, 7090% reduction of the mitochondrial membrane potential and 610-fold increase in LDH or ALT release
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doi: 10.1016/j.intimp.2023.110777
