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Description
The alcohol-based formulas can be harsh, especially with twice-daily application

Pober JS, Sessa WC

NNMT and NAD Metabolism By methylating nicotinamide, NNMT consumes NAM that would otherwise feed into the salvage pathways for NAD synthesis , thereby reducing intracellular NAD levels

Pain scores (VAS, WOMAC) showed numerical but not statistically significant improvements in most trials
