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The synergistic cooperation of Neh4 and Neh5 to recruit a coactivator molecule called CBP (cAMP Responsive Element-Binding protein (CREB)-binding protein) has been suggested [288]

Adjunctive approaches involving topical calcineurin inhibitors or corticosteroids in conjunction with phototherapy have yielded improved regimentation outcomes [209, 210], while emerging combinations with antioxidants and laser therapies offer additional therapeutic potential, albeit with limited clinical data to date [211]

Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E

Sleep disturbances increase the risk of dementia: A systematic review and meta-analysis