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M1 macrophages exhibit dysregulated iron metabolism, with increased expression of hepcidin (Hamp) and ferritin heavy/light chains (FTH/FTL), and reduced expression of ferroportin (FPN) and IRP1/2 (88)

125 Accordingly, genes encoding MMR components such as mutS homolog 2 (MSH2) and mutL homolog 1 (MLH1) are frequently mutated or downregulated in the context-acquired CDDP resistance

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