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One main limiting factor for successful IS therapeutic intervention is stroke-induced bloodbrain barrier (BBB) damage, particularly over tight junction proteins (TJs)

(4) The authors suggested that intracellular ATP may not be homogeneously distributed in muscle cells or be capable of rapid and efficient diffusion

Monocytes and macrophages are increasingly recognized as key contributors to disease pathogenesis (85)

System Xc - -related cystine transportation is important to maintain intracellular cysteine levels as it is a critical precursor for glutathione (GSH) synthesis [61] serving as a co-factor for glutathione peroxidase 4 (GPX4) to detoxify lipid peroxides [12]