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Environmental factors such as heavy metal toxicity [1012], sub-clinical viral infections [13] and gastro-intestinal pathology [14, 15], as well as endogenous toxins produced by metabolic processes [16], hormones (reviewed in [17]) and gastro-intestinal bacteria [18, 19] have also been suggested as playing a role in the aetiology of the disorder, although none of these have been thoroughly investigated

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Its noteworthy that only five countries, namely the United States, Japan, Brazil, Germany, and Italy account for 58% of ESRD patients worldwide, with Japan topping the list followed by Taiwan