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Description
MDHAR activity has been detected in several cell compartments, such as chloroplasts, mitochondria, peroxisomes and cytosol (Jimenez et al., 1997
In addition, Irg1-deficient phagocytes, which cannot produce itaconate, have shown increased susceptibility to M.tb infection, with infected mice exhibiting higher bacterial loads, reduced survival, exacerbated inflammation, extensive necrotizing granuloma formation and elevated neutrophil infiltration in the lungs [104, 105]
Adequate dietary protein supports collagen matrix
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