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Increased levels of 5-HT in peripheral blood could activate pancreatic -cells and increase their proliferation through the 5-HT3 receptor, leading to increased release of insulin and 5-HT by these cells [282]

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In such a case, alternative therapeutic approaches need to be considered, and our SNAT-3 and SNAT-5 cKO models may serve as appropriate animal models for the development of novel antidepressants to offset esketamine