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This has led to the concept of a nuclear redox cycle that occurs during mitosis in which GSH moves into the nucleus during G1, promoting oxidation of the cytosol and enhanced glutathione accumulation (Diaz-Vivancos et al., 2010b)
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Cardiol Clin 23(3):319330
420 Notably, multitarget agents like Brequinar (DHODH/FSP1) exploit the systems redundancy, selectively targeting cancer cells, especially in OXPHOS-dependent or immunotherapy-resistant malignancies
