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The genetically-encoded biosensor proved to be versatile, as exemplified by its functionality in a series of evolutionary distant organisms (bacteria, plants and animals), different subcellular localizations (cytosol, mitochondria, chloroplasts) and in combination with nutritional, metabolic, pharmacological and genetic perturbations

Mitochondrial permeability transition-driven necrosis is characterized by cyclophilin D-mediated opening of the permeability transition pore, which is induced by excessive production of ROS and Ca 2+ overload of the mitochondrial matrix [65]

After years of research and clinical experience, I discovered the optimal form, molecular structure, and delivery method glutathione needs to have have maximum impact

It seems possible that inactivation of ATP synthase by a wide range of electrophiles may interfere with apoptotic cell death pathways