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Hao Y, Pang Y, Yan H, Zhang Y, Liu J, Jin L, et al

IGF Binding Proteins and Bioavailability The mechanism underlying this enhanced potency relates to IGF-1's complex regulatory system involving IGF binding proteins (IGFBPs), a family of six high-affinity binding proteins (IGFBP-1 through IGFBP-6) that normally sequester the vast majority of circulating IGF-1 and regulate its bioavailability, half-life, and access to cell surface IGF-1 receptors

doi: 10.1126/science.3029864 85 StockwellB

therefore, any intervention that improves the health of the gut microbiome and resolves dysbiosis could also theoretically restore the healthy function of the intestinal barrier