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Because the vitamins C, E and gamma-tocopherol, co-enzyme Q10 as well as iron, copper, zinc, manganese and selenium function as radical scavengers or cofactors of antioxidant enzymes, reactive oxygen species will increase and interfere with intermediary folate metabolism and the folate transport mechanisms provided by FR and RFC1

With regards to the impact of the probiotic on antimicrobial treatment, the results revealed no major compositional shifts on microbiota with probiotic, compared to placebo

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For example, alpha lipoic acid is known for its antioxidant role in cellular energy metabolism, green tea polyphenols are studied for protection against oxidative damage, grape seed and pine bark extracts are associated with microcirculation and collagen support, while biotin, zinc, and vitamins A, C, and E contribute to normal skin maintenance