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Under acute hypobaric hypoxia, the body adapts to the external environment by changing a series of gene expressions, and hypoxia inducible factor-1 (HIF-1) is the most important transcription factor that regulates cellular adaptation to hypoxia, which plays a key role in cellular perception and acclimatation to the change of oxygen concentration (Li et al., 2020a)

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Notable upregulation of dihydropyrimidine, acetyl-CoA, and uracil was observed in the beta-alanine metabolism pathway (Figure 4D)