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At neutral to alkaline pH (above 7), deamidation proceeds through a cyclic imide intermediate that produces a mixture of normal and isomerized products

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It does this by messing with the bodys way of taking in B12 in the ileum

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Common causes of temporary post-injection pain include: Local inflammation: The injection itself can irritate surrounding tissues Increased joint pressure: The added fluid volume temporarily stretches the joint capsule Normal healing response: Your bodys natural reaction to any needle puncture Muscle tension: Protective guarding around the injection site According to Cleveland Clinic, this reaction typically manifests as mild pain and swelling at the injection site and resolves without intervention [3]

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Petrovic et al., 2006

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