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1) Pro-angiogenic signaling (VEGFR2 Akt eNOS) In cell and animal models, BPC-157 increases VEGFR2 expression/internalization and activates downstream Akt-eNOS signaling, supporting endothelial tube formation and blood-flow recovery after ischemia
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Metabolic unpredictability: Simultaneously altering multiple metabolic pathways incretin signalling, glucagon activity, and NAD+ metabolism without clinical oversight introduces unpredictable physiological consequences
