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Description
Note: Individual response varies
Unick JL, Hogan PE, Neiberg RH, Cheskin LJ, Dutton GR, Evans-Hudnall G, et al
Given that the complexity of cAMP responses, upon activation of -ARs, depends on the cellular arrangement of the molecular partners of the signaling cascade, it is predictable that localization of the receptors throughout the heterogeneous cell membrane domains, the fractionor specific subsetof receptors activated by the agonist, and the kinetics and potency of activation, are all critical players
Br J Pharmacol 173 : 666680
