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Description
CHH is caused by a variety of different mutations of RMRP (for RNA component of mitochondrial RNA processing endoribonuclease), located on chromosome 9p21-p12 (1, 2, 3, 4, 5, 6, 7)
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This hypothesis is supported by several studies that have shown supplementation with SAM improves depressive symptoms (104-107)
Hypermethylation leads to transcriptional silencing, impairing the ability of tumors to repair alkylating agent-induced DNA damage and thereby increasing their sensitivity to temozolomide (TMZ)
