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At eight weeks post-treatment, 44% of HER2 3+ patients achieved stable disease, accompanied by increased CD8 + T cell infiltration in tumors, suggesting adaptive immune activation via antigen presentation (275)

Varicocele, characterized by increased testicular temperature and local hypoxia, can induce oxidative stress and impair testicular function ( Figure 1c ) ( Endocrine and metabolic disorders also contribute to ROS-mediated spermatogenic damage

[DOI] [PubMed] [Google Scholar] 9.Aon MA, Cortassa S, Maack C, O'Rourke B

This increased oxygen consumption leads to the production of more free radicals and oxidative stress, which causes damage to cells and tissues