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Sources: PMID 18271889, 36986081, 38320260, 38365549, 39186190, 40005053 Saffron is having a moment its kind of amazing because its the most expensive spice in the world yet all of these benefits keep popping up around what it can do as a Supplement

They are N -trimethyllysine hydroxylase, 3-hydroxy- N -trimethyllysine aldolase, 4- N -trimethylaminobutyraldehyde dehydrogenase and -butyrobetaine hydroxylase

Skin changes and temperature dysregulation leading to loss of turgor, dryness and therefore itching and surface breaks are common in cirrhosis and the use of moisturizers to improve hydration and maintain barrier integrity is always the first step toward reducing pruritus (4)

A population-based study on the epidemiology of functional gastrointestinal disorders in young children