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Mechanism of Action NSAIDs inhibit one or both COX enzymes: COX-1 Protects gastric mucosa Maintains renal blood flow Supports platelet aggregation COX-2 Induced during inflammation Produces prostaglandins involved in pain, swelling, and fever Traditional NSAIDs block both COX-1 and COX-2

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NaBPC157 (10 g or 10 ng/kg b.w., i.p.) or saline (5.0 ml/kg b.w., i.p.) was applied either 1 hour before or 1 hour after both carotid arteries were ligated for 3 or 6 hours in rats

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