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Description
In a study using a rotenone-induced PD mouse model, combined with antibiotic-induced microbiome depletion and fecal microbiota transplantation, it was found that gut microbiota dysbiosis, along with leaky gut-induced bacterial endotoxins, activates C/EBP/AEP signaling and -syn pathology, ultimately leading to neurodegeneration in PD (52)
doi: 10.3389/fnut.2023.1143385

The hearts constant need for energy expenditure and its heavy dependence on fatty acids (the cardiac muscle obtains 5070% of its energy from fatty acids) explain why patients with primary carnitine deficiency can develop cardiomyopathy, usually between 1 and 4 years of age, that responds poorly to standard therapy [3, 90, 106108]

Holck A, Wolkowitz O, Mellon S, Reus V, Nelson J, Westrin , et al
