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Glycine Catabolism Glycine is classified as a glucogenic amino acid, since it can be converted to serine by serine hydroxymethyltransferase, and serine can be converted back to the glycolytic intermediate, 3-phosphoglycerate or to pyruvate by serine/threonine dehydratase, although the latter reaction (serine to pyruvate) appears not be occur in human tissues

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Thus, PI3K/AKT/CREB/BDNF/TrKB hub may be regarded as a striking therapeutic objective for the amelioration of neurodevelopmental disorders, like ADHD
