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L-Carnitine and its corresponding derivative containing 2 carbons in the acyl moiety (acetyl-L-carnitine) are taken up into cells via the organic cation transporter novel 2 (OCTN2) which cotransports L-carnitine with Na + [43, 44]

Warnings Hypersensitivity Reactions Serious hypersensitivity reactions, including anaphylaxis, laryngeal edema, and bronchospasm have been reported following levocarnitine administration, mostly in patients with end stage renal disease who are undergoing dialysis

Acknowledgments The authors thank the administrative staff (Roberta Saragozza and Fabiola Lobinu) for the formalization of the collaboration contracts, Gaetano Malgieri (DISTABiF

TH also regulates the expression of the sarcoplasmic/endoplasmic reticulum Ca 2+ -dependent ATPase (SERCA) in skeletal muscle (235, 237, 284)