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In many disease states (i.e., renal disease, obesity), an enhanced or minimally maximal support of body lean is associated with quality of life and is a nutritional goal in aiding in the management of the disease

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[DOI] [PubMed] [Google Scholar] Trebak M, Lemonnier L, DeHaven WI, Wedel BJ, Bird GS, Putney JW., Jr Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channels