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The generation of oxidative DNA lesions, such as 8-oxoguanine (8-oxoG), is linked to the development of various cancers, including melanoma, while the accumulation of these lesions can compromise genomic stability, leading to mutations and the eventual transformation of normal cells into malignant ones 53

therefore, the cytotoxic effect of everolimus is significantly higher (185 times) in LN229 cells when transported by high-density lipoprotein (HDL) nanoparticles, while free everolimus is only 3.2 times more effective against U87 cells [421]

Building upon this evidence, we propose that limited extracellular CAT pool in serum is particularly vulnerable to oxidative modification through direct exposure to APP-derived reactive species, which may account for its diminished activity

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