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Chen H., Are We Ready for a Potential Increase in Parkinson Incidence?, JAMA Neurology 73, no
225 In addition to its role in metabolism, HIF-1 contributes to GBM invasiveness by promoting EMT through the activation of the Snail and ZEB1 transcription factors, downregulating E-cadherin, and enhancing ECM remodeling
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This activation leads to increased thermogenesis, improved mitochondrial function, and enhanced insulin sensitivity
