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In normal physiological conditions, various cellular activities generate reactive oxygen species (ROS), and the presence of counteractive antioxidant molecules serve as electron donors to neutralize and inhibit the accumulation of ROS, ensuring the integrity of the genome and other cellular protein structures

Integrative Medicine: A Clinician's Journal , 19 (1), 12

Finally, epigenetic regulation via histone modification, such as acetylation of methylation at the NLRP3 promoter and DNA methylation, silences NLRP3 expression and further refines its transcriptional control, highlighting the intricate regulation of this critical inflammasome component [52]