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The oligonucleotide primers were shown as follows: Hif3 (sense: 5-TCGTGCATTCTCATGAGCCC-3, antisense: 5-GTTCCTGGGCTGGACAGTTT-3), Mmp8 (sense: 5-CCAATGCCTTCCCAGTACCTGA-3, antisesce: 5-GGCATTCCTCGAAGACCGGAAT-3), Timp1 (sense: 5- CTATAGTGCTGGCTGTGGGG-3, antisense: 5-GGACCTGATCCGTCCACAAA-3), Fam187b (sense: 5 ACCAACCAGCCGTACTTTGT3, antisense: 5-TTGTCAGCTTCCCAGTGGAC-3)

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But for the major therapeutic peptides used in aesthetic and longevity protocols, injectable delivery is the baseline for reliable results

In contrast, the NP and ND locations displayed significant changes in BSC spectrum-related parameters (Fig