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Reducing paracetamol overdoses
Reportedly, NF-B activation has anti- oxidant and pro-oxidant roles, the former involves the suppression of ROS accumulation, autophagy promotion, Inhibition of JNK activation and increased anti-oxidant targets whereas the pro-oxidant role includes the induction of pro-oxidation genes
doi: 10.1016/j.tice.2025.103092
The heterozygous CT genotype has an intermediate effect but is closer to the TT genotype than CC
