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Additional testing may be required to obtain a complete understanding of metabolic function

Several additional THR agonists are undergoing clinical evaluation, including ASC41 (phase II, China) (163, 164), HSK31679 (early study) (162), TERN-501 (165) (phase IIa), Sobetirome (GC-1, half before phase II) (164, 166), Eprotirome, Sobetirome, exhibited lipid-lowering effects in phase I trials under both single and multiple dosing regimens

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ABCD1 exhibits highest affinities for very hydrophobic saturated very long-chain fatty acids (C24:0C26:0)