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GSEA analysis revealed significant enrichment of IFN-I signaling pathways in the Lig group (Fig S6a), while the corresponding heatmap analysis confirmed upregulation of IFN-Iresponsive genes in Lig-derived neutrophils (Fig S6b)

31 There was a notable increase in glutamine after LPS administration, while no increases were found in glutathione, glutamate, or related amino acids, indicating that the body tried to modulate the anti-inflammatory response during the organ damage

The brain is especially sensitive to oxidative stress