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Genetic testing is also available for breeds that are prone to inherited selective cobalamin malabsorption

GNDF exerts its effects by binding to the GDNF family receptor tyrosine kinase (GFR-1)

The established safety profiles of these GH secretagogues in defined populations make them particularly attractive candidates for off-label use in musculoskeletal recovery

In particular, a study of the metabolome and of mitochondrial function in a small group of children with 22q11.2DS revealed a distinct biochemical profile, which was consistent with increased oxidative stress, and shared features with congenital propionic and/or methylmalonic acidaemia (6)