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Psychiatry 4:52

As indicated above, lactate stimulates the HCA1 receptor on adipocytes leading to decreased cAMP production

If k 12 and k 21 are first-order rate constants that govern the rate of drug change in and out of the tissues, then the change in drug concentration in the tissue with time could be calculated from the following equation: And since then where p represents the amount of drug in the central compartment, t is the amount of drug in the tissue compartment, p represents the volume of drug in the central compartment, and t is the volume of drug in the tissue compartment